Sitagliptin mechanism of action ,dosage

Sitagliptin is used to manage Type-2 Diabetes. It is a popular choice of drug for those suffering from this ailment owing to its safety profile and ease of administration, which is usually oral. In this article, we will delve into its details:

Sitagliptin is used to manage Type-2 Diabetes in adults. It is mainly used when blood sugar levels cannot be controlled with diet and exercise alone. It can be used as a stand-alone drug and also in combination with other anti-diabetic medicines.

The recommended drug use is 100mg daily which can be taken with or without food. Its dosage can be changed according to the patient’s condition and how they react to the drug. A close watch is kept on the individual’s kidney function to gauge the drug effect more closely.

Sitagliptin works by blocking an enzyme called Dipeptidyl Peptidase-4, which leads to higher levels of active incretin hormones and glucose-dependent insulinotropic polypeptide. These hormones help regulate blood sugar levels. Sitagliptin ensures that the incretin hormones remain active for longer periods, helping the body to manage the blood sugar level more effectively, particularly after meals.

This drug can be used alone for those who have any form of adverse reaction to other antidiabetic drugs. It is also used in combination with other drugs to achieve better control of blood sugar levels.

Although the drug is safe, it does come with a few side effects. This includes headache, stomach ache, breathlessness, and nausea. The drug is well-tolerated by most users, however, in case one has a history of allergies or adverse reactions to drugs, it's best to keep the doctor informed. Regular observation of blood glucose levels is important to monitor the effectiveness of the drug and make changes to it as needed.

Sitagliptin mechanism of action ,dosage

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